Hypothermia

Research has confirmed the importance of body temperature to outcome in cerebral ischemic events. Fever often accompanies stroke or brain trauma and prompt measures are advised to maintain normal core-body temperature. A direct correlation has been observed between reduced body temperature and improved outcome following brain injury or disorder. The administration of a non-opioid analgesic such as acetaminophen (common Tylenol) in conjunction with an Endothelin receptor antagonist such as BQ-123 has been shown in animal models to significantly enhance the fever reducing effect of acetaminophen. EndogenX believes that the use of a non-opioid analgesic in combination with an Endothelin antagonist may significantly improve the neurological outcome for victims of stoke and brain trauma.

	Research		PreClinical		Clinical		Market
ENDG5020 Hypothermia